Antisense RNA targeting PMP22 for the treatment of Charcot-Marie-Tooth 1A disease

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United States of America

PATENT NO 11939577
SERIAL NO

17279206

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Abstract

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The present invention relates to antisense RNAs targeting PMP22 and able to inhibit from 40% to 60% the expression of PMP22 in the cells and a pharmaceutical composition comprising thereof. The antisense RNAs are preferably siRNA and are preferably provided in the form of nanoparticles. The present invention also relates to the use of these antisense RNAs targeting PMP22 for the treatment of Charcot-Marie-Tooth 1A disease.

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Patent Owner(s)

Patent OwnerAddress
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE3 RUE MICHEL ANGE PARIS 75015
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)101 RUE DE TOLBIAC PARIS 75013

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Boutary, Susan Arcueil, FR 1 0
Couvreur, Patrick Paris, FR 40 743
Desmaële, Didier Fresnes, FR 1 0
Massaad, Charbel Arcueil, FR 2 3
Massade, Liliane Cachan, FR 2 1
Urbinati, Giorgia Maria Laura Paris, FR 1 0

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