Method for producing cyclized peptide having intramolecular S-S bond

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United States of America Patent

PATENT NO 11939404
APP PUB NO 20210277063A1
SERIAL NO

17319346

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Abstract

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Cyclized peptides having a crosslinked structure by one or more intramolecular S—S bonds may be prepared by:

    (1-A) as to a completely protected linear peptide having two or more SH groups as functional groups on the peptide, removing protecting groups of all functional groups other than the protected SH groups in the peptide,(1-B) protecting all SH groups of the linear peptide having two or more SH groups as the functional groups on the peptide by forming a temporary S—S bond,and(2) subjecting the peptide obtained by step (1-A) and step (1-B) to a folding step under oxidation and reduction conditions to obtain the cyclized peptide by re-forming an S—S bond in the peptide molecule.

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Patent Owner(s)

Patent OwnerAddress
AJINOMOTO CO INCJAPAN'S TOKYO CENTRAL BEIJING A CHOME 15 NO 1 TOKYO TOKYO METROPOLIS

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Inomata, Tatsuji Yokkaichi, JP 2 0
Shinohara, Yuki Yokkaichi, JP 30 86
Takahashi, Daisuke Kawasaki, JP 266 1309

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