Engineered transaminase polypeptides and uses thereof

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United States of America Patent

PATENT NO 11932886
APP PUB NO 20200332321A1
SERIAL NO

16761785

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Abstract

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Provided are amino acid sequences of engineered transaminase polynucleotide that are useful for asymmetrically synthesizing chiral amine compounds, and its preparation process and reaction process under industrial-relevant conditions. Also provided are polynucleotide sequences encoding engineered transaminase polypeptides, engineered host cells capable of expressing engineered transaminase polypeptides, and methods of producing chiral amine compounds using engineered transaminase polypeptides. Compared to other enzymes, the engineered transaminase polypeptides provided by this invention have better catalytic activity and stability, and are not inhibited by chiral amine products in the synthesis process. The use of the engineered polypeptides of the present invention for the preparation of chiral amine compound results in higher unit activity, and has good industrial application prospects.

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Patent Owner(s)

Patent OwnerAddress
ENZYMASTER (NINGBO) BIO-ENGINEERING CO LTDROOM 6-21 - (6-27) NO 333 NORTH SECTION OF CENTURY AVENUE YINZHOU DISTRICT NINGBO CITY ZHEJIANG PROVINCE 315042 NINGBO CITY ZHEJIANG PROVINCE 315042

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bocola, Marco Ningbo, CN 10 2
Bong, Yong Koy Ningbo, CN 30 53
Cai, Baoqin Ningbo, CN 9 0
Chen, Haibin Ningbo, CN 96 1781
Shang, Chuanyang Ningbo, CN 2 0
Wang, Juanjuan Ningbo, CN 10 49

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