Polypeptides comprising immunoglobulin single variable domains targeting glypican-3 and T cell receptor

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United States of America Patent

PATENT NO 11932702
APP PUB NO 20220213215A1
SERIAL NO

17553908

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Abstract

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The present technology aims at providing a novel type of drug for treating a subject suffering from cancer. Specifically, the technology provides polypeptides comprising at least four immunoglobulin single variable domains (ISVDs), characterized in that one ISVD binds to TCR and at least two ISVDs bind to GPC3. The present technology also provides nucleic acids, vectors and compositions.

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Patent Owner(s)

Patent OwnerAddress
ABLYNX N VTECHNOLOGIEPARK 21 9052 ZWIJNAARDE BELGIUM

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Boutton, Carlo Wielsbeke, BE 56 373
Dombrecht, Evelyne Zwijnaarde, BE 2 0
Janssen, Daniel Mortsel, BE 6 26
Laukens, Bram Zwijnaarde, BE 5 0
Meoni, Paolo Zwijnaarde, BE 3 0
Pao, Lily Bridgewater, US 2 0
Pype, Jan Herne, BE 11 5
Schotte, Peter De Pinte, BE 28 132
Serruys, Benedikte Sint-Michiels, BE 2 0
Van, Hoorick Diane Laarne, BE 21 122
Vintem, Ana Paula Zwijnaarde, BE 2 0

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