Monoclonal antibodies directed against programmed death-1 protein and their use in medicine

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 11932693
APP PUB NO 20230365693A1
SERIAL NO

18315686

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Abstract

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The present disclosure relates to antibodies having the ability to bind to the immune checkpoint protein programmed death-1 (PD-1), such as human PD-1, or nucleic acids encoding such antibodies, wherein the antibodies comprise modifications in the Fc region eliminating or reducing a Fc-mediated effector function of the antibodies. The present disclosure also relates to compositions or kits comprising said antibodies or nucleic acids, as well as to the use of these antibodies or nucleic acids or compositions in the field of medicine, preferably in the field of immunotherapy, e.g., for the treatment of cancers. The present invention further relates to methods for inducing an immune response in a subject comprising providing to the subject an antibody of the present disclosure or one or more nucleic acids encoding such an antibody, or a composition comprising said antibody or nucleic acids.

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Patent Owner(s)

Patent OwnerAddress
GENMAB A/SCARL JACOBSENS VEJ 30 2500 VALBY DENMARK

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Beckmann, Karsten Mainz, DE 14 69
Blum, Jordan Utrecht, NL 3 0
Breij, Esther Cornelia Wilhelmina Utrecht, NL 7 22
De, Kreuk Bart-Jan Utrecht, NL 6 1
Fellermeier-Kopf, Sina Mainz, DE 11 0
Garrido, Castro Patricia Utrecht, NL 4 0
Gieseke, Friederike Mainz, DE 29 54
Guelen, Lars Utrecht, NL 12 9
Hibbert, Richard Utrecht, NL 6 0
Kuzmanov, Ivan Mainz, DE 4 0
Labrijn, Aran Frank Utrecht, NL 64 1182
Muik, Alexander Mainz, DE 38 36
Neijssen, Joost Utrecht, NL 9 86
Paulmann, Claudia Mainz, DE 5 0
Sahin, Ugur Mainz, DE 331 2329
Schuurman, Janine Utrecht, NL 116 1580

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