Glucose oxidase-nanoparticle bioconjugates for cancer treatment

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United States of America

PATENT NO 11931423
SERIAL NO

16691030

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Bioconjugates and methods of making bioconjugates are provided, wherein the bioconjugates comprise glucose oxidase and nanoparticles that can kill tumor cells. For example, glucose oxidase-iron oxide bioconjugates can produce reactive oxygen species from blood glucose, causing cell death. The use of superparamagnetic iron oxide nanoparticles can provide magnetic resonance imaging guidance to facilitate imaging-guided drug delivery and combine diagnostics with therapy.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION1ST FLOOR GARDNER STEEL CONFERENCE CENTER 130 THACKERAY AVENUE PITTSBURGH PA 15260

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gao, Di Sewickley, US 40 327
Wu, Jiamin Pittsburgh, US 24 44
Zeng, Dexing Pittsburgh, US 11 12

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