Methods of preparing a pegylated human IL-11 composition

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United States of America

PATENT NO 11931417
SERIAL NO

17173783

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Abstract

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Methods are provided for producing a PEGylated interleukin 11 (IL-11) by treating a recombinant IL-11 PEGylated with an equimolar to low molar excess of PEG carrying an amine-reactive group to achieve a highly pure monoconjugate preparation, which provides improved half-life in serum while having desirable therapeutic activity and presenting fewer side-effects. Most preferably, the IL-11 is an N-terminally truncated human or humanized IL-11 and has a 20 Kd or 40 Kd branched PEG moiety, Y- or comb-shaped in particular, coupled to the N-terminal amino group. Such compounds are characterized by substantially increased stability in serum and sustained biological activity while exhibiting significantly reduced plasma expansion.

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Patent Owner(s)

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NANSHA BIOLOGICS (HONG KONG) LIMITED10/5 FUNG HOUSE 19-20 CONNAUGHT ROAD CENTRAL

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Choo, Qui-Lim El Cerrito, US 53 1206
Fok, Manson The Peak, HK 9 1
Lau, Johnson Yiu-Nam Houston, US 56 35
Yu, Kuo-Ming Taipei, TW 10 11

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