Pharmaceutical composition for preventing or treating neurodegenerative diseases comprising COX2 acetylating agent as active ingredient

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United States of America Patent

PATENT NO 11899025
APP PUB NO 20210003594A1
SERIAL NO

16982494

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to a pharmaceutical composition for preventing or treating neurodegenerative diseases comprising a COX2 acetylating agent as an active ingredient and, more particularly, to a pharmaceutical composition for preventing or treating neurodegenerative diseases comprising, as an active ingredient, a COX2 acetylating agent which exhibits an effect of inhibiting the deposition of amyloid-β in brain neurons, reducing excessive neuroinflammatory responses, and increasing the phagocytosis of amyloid-β in microglial cells. The pharmaceutical composition for preventing or treating neurodegenerative diseases comprising the COX2 acetylating agent as an active ingredient has the effects of alleviating neuroinflammation by promoting COX2 acetylation in neurons and secreting specialized pro-resolving mediators (SPMs) and thus, can be very useful in the development of a preventive or therapeutic agent for neurodegenerative diseases.

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Patent Owner(s)

Patent OwnerAddress
KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATIONDAEGU 41566

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bae, Jae-Sung Daegu, KR 39 215
Han, Seung Hoon Daegu, KR 23 60
Jin, Hee Kyung Daegu, KR 27 8
Lee, Ju Youn Daegu, KR 31 318

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