Labyrinthulid microorganism capable of producing microbial oil, microbial oil, methods for producing said microorganism and for producing said microbial oil, and uses of said microorganism and said microbial oil

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United States of America Patent

PATENT NO 11898190
APP PUB NO 20220042052A1
SERIAL NO

17401894

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Abstract

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A method for producing a microbial oil includes steps of: genetically modifying a labyrinthulid by disrupting and/or silencing a gene, or by transforming another gene in addition to the disruption and/or gene silencing of the gene, and culturing the labyrinthulid, such that a fatty acid composition accumulated in the labyrinthulid comprises an increased EPA content; and collecting the microbial oil having the increased EPA content from the labyrinthulid. The labyrinthulid before the modification is selected from (A) a labyrinthulid belonging to the genus Parietichytrium or genus Schizochytrium and having very weak or no activity of producing PUFAs via a PUFA-PKS pathway; and (B) a labyrinthulid belonging to the genus Thraustochytrium in which a host PUFA-PKS gene is disrupted or silenced to a very weak level. The increased EPA content is preferably not less than 11.5% of a total fatty acid composition.

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Patent Owner(s)

Patent OwnerAddress
NIPPON SUISAN KAISHA LTD3-1 NISHI-SHINBASHI 1-CHOME MINATO-KU TOKYO 105-8676
KYUSHU UNIVERSITY NATIONAL UNIVERSITY CORPORATION744 MOTOOKA NISHI-KU FUKUOKA-SHI FUKUOKA 819-0395
KONAN GAKUEN8-9-1 OKAMOTO HIGASHINADA-KU KOBE-SHI HYOGO 6588501

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Goda, Hatsumi Fukuoka, JP 3 0
Hamaguchi, Rie Fukuoka, JP 7 21
Honda, Daisuke Kobe, JP 90 300
Ito, Makoto Fukuoka, JP 297 2381
Mochinaga, Seiya Fukuoka, JP 3 0
Okita, Yuji Hachioji, JP 40 125

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