Bioreactor and method of forming complex three-dimensional tissue constructs

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United States of America Patent

PATENT NO 11898132
APP PUB NO 20210348105A1
SERIAL NO

17380833

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Abstract

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A bioreactor and method of forming complex three-dimensional tissue constructs in a single culture chamber. The bioreactor and methods may be used to form multi-phasic tissue constructs having tissue formed from multiple cell types in a single culture chamber. The bioreactor includes at least one translation mechanism to facilitate translation of one or more tissue constructs without direct user intervention, thereby providing a closed, sterile environment for complex tissue fabrication. The bioreactor may be used as a stand-alone device or as part of a large-scale system including many bioreactors. The large-scale system may include a perfusion system to monitor and regulate the tissue culture environment.

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THE REGENTS OF THE UNIVERSITY OF MICHIGANANN ARBOR MI 48109-2590

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Arruda, Ellen M Ann Arbor, US 18 146
Larkin, Lisa M Ann Arbor, US 10 51
Moncada-Larrotiz, Pablo Ann Arbor, US 3 5
Smietana, Michael J Ann Arbor, US 4 5

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