Monoclonal antibody binding to TIGIT antigen, preparation method and use thereof

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United States of America Patent

PATENT NO 11897955
APP PUB NO 20230272064A1
SERIAL NO

17915109

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Abstract

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A monoclonal antibody or a derivative thereof that binds to a human TIGIT antigen with high-affinity and antagonistically inhibits the binding of TIGIT to a ligand thereof such as CD155 is provided. Amino acid sequences of antigen complementarity-determining regions CDR-L1, CDR-L2 and CDR-L3 of an antibody light chain variable region, and amino acid sequences of antigen complementarity-determining regions CDR-H1, CDR-H2 and CDR-H3 of an antibody heavy chain variable region are specified. Further, a humanization preparation method for the antibody and amino acid sequences of the heavy chain variable region and light chain variable region of the humanized antibody are provided. The antibody or the derivative thereof can serve as an ingredient of a pharmaceutical composition or can be prepared into an appropriate drug preparation, and administered alone or in combination with other medications, such as an anti-PD-1 monoclonal antibody, or treatment means, for treating diseases such as tumors.

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Patent Owner(s)

Patent OwnerAddress
ACROIMMUNE BIOTECH CO LTD#602 BUILDING 1 PHASE 3 INTERNATIONAL BIOLOGICAL ISLAND GUANGZHOU GUANGDONG 510320 (CN) GUANGZHOU 510320

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Zui Suzhou, CN 5 33
Fan, Jinling Suzhou, CN 3 1
Hu, Hongqun Suzhou, CN 5 33
Ma, Xiaoxiao Suzhou, CN 16 45
Sun, Weiwei Suzhou, CN 19 133
Zhou, Qunmin Suzhou, CN 8 41

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