Probe for selectively characterizing enzymes involved in xenobiotic metabolism and method of making and using the same
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United States of America Patent
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Feb 6, 2024
Grant Date -
Sep 8, 2022
app pub date -
Apr 26, 2022
filing date -
Oct 4, 2017
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Abstract
Activity-based probes that can be used to selectively identify and characterize enzymes that are involved in different phases of xenobiotic metabolism in a host and its microbiota population(s) are described. The activity-based probes described specifically label only their target active enzymes involved in xenobiotic metabolism and therefore provide a measurement of true protein functional activity rather than transcript or protein abundance. The activity-based probes also provide multimodal profiling of these active enzymes. Methods for preparing the activity based probes and exemplary methods for their use also are disclosed.
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