Adeno-associated virus compositions for restoring F8 gene function and methods of use thereof

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 11891619
APP PUB NO 20220333138A1
SERIAL NO

17654300

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Abstract

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Provided herein are adeno-associated virus (AAV) compositions that can restore F8 gene function in a cell without co-transducing or co-administering an exogenous nuclease or a nucleotide sequence that encodes an exogenous nuclease. Also provided are methods of using the AAV compositions to correct an F8 gene mutation and/or treat a disease or disorder associated with an F8 gene mutation. Packaging systems for making the adeno-associated virus compositions are also provided.

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CITY OF HOPE1500 E DUARTE ROAD DUARTE CA 91010

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chatterjee, Saswati Altadena, US 29 805
Ellsworth, Jeff Lynn Lexington, US 38 2887
McSwiggen, James Anthony Arlington, US 12 119
Rubin, Hillard Northborough, US 11 30
Smith, Laura Jane Bedford, US 18 345
Wright, Jason Boke Bedford, US 11 12

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