Glycosylation of variable immunoglobulin domains

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United States of America Patent

PATENT NO 11891451
APP PUB NO 20200148790A1
SERIAL NO

16612476

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Abstract

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The present invention provides nucleotide sequences encoding polypeptides comprising immunoglobulin variable domains with engineered glycosylation acceptor sites. Specifically, the invention provides immunoglobulin variable domain proteins modified with selected glycans and specific glycan-conjugates thereof. Also provided herein are methods for the production of glycosylated immunoglobulin variable domains and glycan-conjugates thereof.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITEIT GENT9000 GENT
VIB VZWRIJVISSCHESTRAAT 120 GENT B-9052

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Callewaert, Nico Nevele, BE 25 118
Laukens, Bram Ghent, BE 5 0
Nerinckx, Wim Astene, BE 4 2
Van, Breedam Wander Antwerp, BE 5 2
Van, Schie Loes Ghent, BE 6 2

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