Selective androgen receptor degrader (SARD) ligands and methods of use thereof

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United States of America Patent

PATENT NO 11873282
APP PUB NO 20210253525A1
SERIAL NO

17027707

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Abstract

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This invention provides novel indole, indazole, benzimidazole, benzotriazole, indoline, quinolone, isoquinoline, and carbazole selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating hyperproliferations of the prostate including pre-malignancies and benign prostatic hyperplasia, prostate cancer, advanced prostate cancer, castration resistant prostate cancer, other AR-expressing cancers, androgenic alopecia or other hyper androgenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels (through degradation) and/or activity (through inhibition) of any androgen receptor including androgen receptor-full length (AR-FL) including pathogenic and/or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION400 W SUMMIT HILL DRIVE - UT TOWER 961A KNOXVILLE TN 37902

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
He, Yali Germantown, US 44 1310
Hwang, Dong-Jin Arlington, US 30 254
Miller, Duane D Collierville, US 179 4313
Narayanan, Ramesh Cordova, US 56 684
Ponnusamy, Thamarai Memphis, US 34 267

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