Methods, systems, and apparatuses for tissue ablation using electrolysis and permeabilization

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United States of America Patent

PATENT NO 11866833
APP PUB NO 20210220532A1
SERIAL NO

17221737

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Abstract

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Example apparatuses and systems are disclosed for providing controlled delivery of electrolysis treatment and cellular permeabilization treatment to a site in tissue. A system disclosed may include an electrode, a power supply, and a controller. The controller may control a charge applied to the electrode to induce a direct current through the aqueous matrix to produce electrolysis products and a voltage to produce electroporation. The duration and magnitude of the charge applied may determine the dose of the products and the degree of the permeabilization of cells in the treatment site. The composition of the electrodes may be chosen in accordance with the desired products produced and electroporation effects. An apparatus is disclosed that may be in the form of electrodes for electrolysis and electrodes for electroporation applied to the tissue. An apparatus is disclosed that may be used for treating internal tissue.

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Patent Owner(s)

Patent OwnerAddress
RM2 TECHNOLOGY LLC78 SW 7TH STREET SUITE 800 MIAMI FL 33131

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Mikus, Paul Rancho Mission Viejo, US 48 2869
Rubinsky, Boris El Cerrito, US 114 9708
Rubinsky, Liel El Cerrito, US 13 277

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