Aminoglycosides and uses thereof in treating genetic disorders

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United States of America Patent

PATENT NO 11865128
APP PUB NO 20210228608A1
SERIAL NO

17226050

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Abstract

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A new class of pseudo-trisaccharide aminoglycosides having an alkyl group at the 5″ position, exhibiting efficient stop codon mutation readthrough activity, low cytotoxicity and high selectivity towards eukaryotic translation systems are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders, as well as processes of preparing these aminoglycosides. The disclosed aminoglycosides can be represented by the general formula I:

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Patent Owner(s)

Patent OwnerAddress
TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITEDSENATE HOUSE TECHNION CITY HAIFA 3200004

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Atia-Glikin, Dana Schania, IL 7 59
Baasov, Timor Haifa, IL 30 157
Belakhov, Valery Haifa, IL 16 104
Kandasamy, Jeyakumar Trichy, IN 7 59

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