Methods of inhibiting pathological angiogenesis

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United States of America Patent

PATENT NO 11865123
SERIAL NO

17412003

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Abstract

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This invention is based on the discovery that many eye conditions associated with aging are mediated at least in part by cells bearing a senescent phenotype. Senescent cells accumulate with age, and express factors that contribute to the pathophysiology of age related conditions. The data show that in age-matched patients, the severity of age-related conditions correlates with the abundance of senescent cells, and that clearing senescent cells can help abrogate the condition. Small molecule drugs that remove senescent cells from affected tissue in the eye are provided that have special efficacy in treating ophthalmic conditions. They not only inhibit progression of the disease, they can also reverse some of the pathophysiology—such as neovascularization and vaso-obliteration—that lead to vision loss. These senolytic agents have an appropriate dose and specificity profile to be effective in the clinical management of previously intractable ophthalmic conditions.

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Patent Owner(s)

Patent OwnerAddress
UNITY BIOTECHNOLOGY INC3280 BAYSHORE BLVD BRISBANE CA 94005

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dananberg, Jamie South San Francisco, US 6 8
David, Nathaniel South San Francisco, US 43 344
Hopkins, Jill South San Francisco, US 3 8
Marquess, Daniel South San Francisco, US 72 914
Poon, Yan South San Francisco, US 17 37
Sweigard, Harry South San Francisco, US 3 8
Tsuruda, Pam South San Francisco, US 3 8

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