Glycyrrhetinic acid derivatives for use in treating hyperkalemia

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United States of America Patent

PATENT NO 11858959
SERIAL NO

17429599

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Abstract

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The present invention provides a compound of formula (I) or a salt thereof: (Formula (I)) wherein X, L, V, R1; R2, R3 and R4, are as defined herein. The claimed compounds inhibit the enzyme 11-hydroxysteroid dehydrogenase type 2 (11-HSD2) and as a result are useful in the treatment of hyperkalemia by preventing cortisol from being oxidised to cortisone and thus allowing it to occupy the mineralocorticoid receptor, thus stimulating potassium excretion.

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Patent Owner(s)

Patent OwnerAddress
ARDELYX INC34175 ARDENWOOD BLVD SUITE 200 FREMONT CA 94555

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Tao Fremont, US 1089 14323
Dragoli, Dean Fremont, US 19 31
Leadbetter, Michael Fremont, US 11 22
Lewis, Jason Fremont, US 76 920
Luehr, Gary Fremont, US 13 13

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