GPCR heteromer inhibitors and uses thereof

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 11857600
APP PUB NO 20200360478A1
SERIAL NO

16885196

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Abstract

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This invention relates to inhibitors of CXC receptor 4 (CXCR4)-G protein-coupled receptor (GPCR) heteromers (CXCR4-GPCR heteromers) associated with cancers, where CXCR4 forms a functional heteromer with other G protein-coupled receptors (GPCRx). More specifically, this invention relates to GPCRx that form heteromers with CXCR4, which upon co-stimulation with CXCR4 agonists and GPCRx agonists leads to enhanced signaling downstream of CXCR4. This invention also provides for the use of inhibitors of the interacting GPCR partner of the CXCR4-GPCRx heteromer or CXCR4-GPCRx heteromer-specific inhibitors including inhibitors of the formation of the CXCR4-GPCRx heteromer and CXCR4-GPCRx heteromer-specific antibodies, and in the diagnosis and/or therapy for cancer.

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Patent Owner(s)

  • GPCR THERAPEUTICS, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Huh, Won-Ki Seoul, KR 2 5
Jeong, Jae-Yeon Seoul, KR 6 217
Kim, Eunhee Seoul, KR 15 18
Kim, SoHui Seoul, KR 3 5
Lee, Jiyeong Seoul, KR 13 63
Lee, Milim Seoul, KR 15 18
Park, Chul O Seoul, KR 2 5
Park, Hyeryung Seoul, KR 2 5
Seen, DongSeung Seoul, KR 3 5
Song, Yong Bhum Daejeon, KR 2 5
Yang, Chang Soo Seoul, KR 34 233

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