Composition and methods for inducing myeloid suppressive cells and use thereof
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United States of America Patent
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Dec 26, 2023
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Apr 2, 2020
app pub date -
Jun 13, 2018
filing date -
Jun 13, 2017
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Abstract
Compositions and methods for manufacturing induced immune regulatory cells comprising induced myeloid suppressive cells including MDSCs (myeloid-derived suppressor cells), dendritic cells, macrophages, and subpopulations thereof are provided. Also provided are methods and compositions for further modifying and modulating the induced immune regulatory cells to achieve enhanced therapeutic potential in treating autoimmune disorders, hematological malignancies, solid tumors, viral infections, neurodegenerative disorders, inflammatory conditions, or GvHD.
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