Preparation of factor Xa derivatives

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United States of America Patent

PATENT NO 11845966
APP PUB NO 20210348149A1
SERIAL NO

17196172

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Abstract

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The present disclosure provides methods for manufacturing a fXa derivative protein at large scale leading to high yield of highly pure protein product. The method may include adding a detergent to a sample that contains a polynucleotide construct encoding the protein and purifying the protein through a soybean trypsin inhibitor (STI)-based affinity chromatograph, an ion exchange and mixed mode chromatograph and a hydrophobic interaction.

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Patent Owner(s)

Patent OwnerAddress
ALEXION PHARMACEUTICALS INC100 COLLEGE ST LEGAL-IP NEW HAVEN CT 06510

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Conley, Pamela B Palo Alto, US 40 173
Karbarz, Mark South San Francisco, US 9 8
Lu, Genmin Burlingame, US 43 330

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