HSD17B13 variants and uses thereof

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United States of America Patent

PATENT NO 11845963
APP PUB NO 20180216084A1
SERIAL NO

15875192

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Abstract

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Provided are compositions related to HSD17B13 variants, including nucleic acid molecules and polypeptides related to variants of HSD17B13, and cells comprising those nucleic acid molecules and polypeptides. Also provided are methods related to HSD17B3 variants. Such methods include methods for detecting the presence of the HSD17B13 rs72613567 variant in a biological sample comprising genomic DNA, for detecting the presence or levels of any one of variant HSD17B13 Transcripts C, D, E, F, G, and H, and particularly D, in a biological sample comprising mRNA or cDNA, or for detecting the presence or levels of any one of variant HSD17B13 protein Isoforms C, D, E, F, G, or H, and particularly D, in a biological sample comprising protein. Also provided are methods for determining a subject's susceptibility to developing a liver disease or of diagnosing a subject with liver disease.

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Patent Owner(s)

Patent OwnerAddress
REGENERON PHARMACEUTICALS INC777 OLD SAW MILL RIVER ROAD TARRYTOWN NY 10591-6707

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Abul-Husn, Noura S Tarrytown, US 8 28
Baras, Aris Tarrytown, US 75 32
Cheng, Xiping Tarrytown, US 16 32
Dewey, Frederick E Tarrytown, US 9 42
Gottesman, Omri Tarrytown, US 44 139
Gromada, Jesper Tarrytown, US 79 208
Li, Alexander Tarrytown, US 12 28
Shuldiner, Alan Tarrytown, US 26 46
Xin, Yurong Tarrytown, US 14 32

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