PRMT5 inhibitors

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United States of America Patent

PATENT NO 11845760
SERIAL NO

17552016

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Abstract

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Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders. Compounds of Formula I have the following structure:

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Patent Owner(s)

Patent OwnerAddress
AMGEN INCONE AMGEN CENTER DRIVE THOUSAND OAKS CA 91320-1799

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Booker, Shon Sherman Oaks, US 58 1655
Bourbeau, Matthew Paul Woodland Hills, US 15 26
Butler, John R Thousand Oaks, US 11 21
Glad, Sanne Ormholt Schroder Ballerup, DK 4 0
Lanman, Brian Alan Woodland Hills, US 48 620
Lopez, Patricia Woodland Hills, US 69 1004
Manoni, Francesco Newbury Park, US 9 1
Pettus, Liping H Thousand Oaks, US 46 545
Sarvary, Ian Greve, DK 11 11
Tamayo, Nuria A Newbury Park, US 40 502
Vestergaard, Mikkel Greve, DK 5 5
Weires, Nicholas Anthony Thousand Oaks, US 5 0

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