Proline hydroxylase and uses thereof

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United States of America Patent

PATENT NO 11827909
APP PUB NO 20210095262A1
SERIAL NO

17118169

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Abstract

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Provided are a proline hydroxylase and uses thereof. The proline hydroxylase comprises having the amino acid sequence of SEQ ID NO: 2 with the exception of a mutation of one or more amino acids; wherein the mutation of one or more amino acids must comprises E27K, and the mutation of one or more amino acids selected from the group consisting of: H14R, L16N, T25R, F26L, E27K, D30S, S33N, E34N, E34G, E34L, E34S, E34D, Y35W, Y35K, S37W, S37F, S37E, S37N, S37T, S37C, W40F, K41E, D54G, H55Q, S57L, I58T, I58Y, I58A, I58R, I58V, I58S, I58C, K86P, T91A, F95Y, C97Y, I98V, K106V, K106T, K106Q, F111S, K112E, K112R, S154A, K162E, L166M, I118F, I118V, I118R, H119R, H119F, I120V, K123D, K123N, K123Q, K123S, K123I, K123T, T130N, D134G, V135K, N165H, D173G, K209R, I223V and S225A, and having proline hydroxylase activity.

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Patent Owner(s)

Patent OwnerAddress
JILIN ASYMCHEM LABORATORIES CO LTDNO 99 HONGDA ROAD ECONOMIC DEVELOPMENT ZONE DUNHUA JILIN 133700
ASYMCHEM LABORATORIES (TIANJIN) CO LTDTIANJIN 300457
ASYMCHEM LIFE SCIENCE (TIANJIN) CO LTDTIANJIN 300457
ASYMCHEM LABORATORIES (FUXIN) CO LTDNO 90 DEVELOPMENT AVENUE FUXIN HIGH-TECH INDUSTRIAL DEVELOPMENT ZONE FUXIN LIAONING 123000
TIANJIN ASYMCHEM PHARMACEUTICALS CO LTDNO 71 XINYE 7TH AVENUE TEDA WEST TIANJIN 300462

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gao, Juan Tianjin, CN 7 3
Hong, Hao Tianjin, CN 68 12
Huang, Xin Tianjin, CN 222 787
James, Gage Tianjin, CN 32 9
Li, Yanjun Tianjin, CN 90 340
Liu, Fang Tianjin, CN 304 1425
Lu, Jiangping Tianjin, CN 25 2
Ma, Yulei Tianjin, CN 11 0
Wei, Junlu Tianjin, CN 2 0
Yu, Wenyan Tianjin, CN 7 0
Zhang, Kejian Tianjin, CN 17 38
Zhang, Na Tianjin, CN 248 911

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