Anti-PD-1/anti-VEGF natural antibody structure like heterodimeric form bispecific antibody and preparation thereof

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United States of America Patent

PATENT NO 11827697
APP PUB NO 20210040193A1
SERIAL NO

16968677

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Abstract

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An anti-PD-1/anti-VEGF natural antibody structure-like heterodimeric form bispecific antibody and preparation thereof. Provided are a highly stable, heterodimeric form anti-PD-1/anti-VEGF bispecific antibody having natural IgG characteristics and free of mismatched heavy and light chains and preparation method for the antibody. The bispecific antibody is capable of simultaneously binding with two target molecules and provides improved efficacy in treating a complicated disease.

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Patent Owner(s)

Patent OwnerAddress
BEIJING HANMI PHARMACEUTICAL CO LTDNO 10 TIANZHU WEST ROAD ZONE A TIANZHU AIRPORT INDUSTRIAL ZONE SHUNYI DISTRICT BEIJING 101318 BEIJING CITY BEIJING CITY 101318

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gu, Mingyue Beijing, CN 1 4
Kim, Maengsup Beijing, CN 11 52
Li, Zhenlei Beijing, CN 6 13
Liu, Jiawang Beijing, CN 19 56
Song, Nanmeng Beijing, CN 13 38
Xiao, Wenchu Beijing, CN 2 5
Yang, Yaping Beijing, CN 25 165
Zhan, Chunguang Beijing, CN 1 4
Zhang, Lina Beijing, CN 40 285

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