Human interleukin-2 conjugates biased for the interleukin-2 receptor beta GAMMAc dimer and conjugated to a nonpeptidic, water-soluble polymer

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United States of America Patent

PATENT NO 11827684
APP PUB NO 20210340207A1
SERIAL NO

17234844

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Abstract

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Interleukin-2 (IL-2) conjugates comprising at least one or more amino acid substitutions that bias binding to the IL-2 receptor βγc dimer over binding the IL-2 receptor αβγc trimer and a non-natural amino acid at or near the N-terminus conjugated to a water-soluble polymer are described. The IL-2 conjugates are useful for treatment and prevention of cell proliferation and cancer in a patient.

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Patent Owner(s)

Patent OwnerAddress
MERCK SHARP & DOHME LLC126 EAST LINCOLN AVENUE RAHWAY NJ 07065

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Abrahams, Cristina Burlingame, US 11 12
Bowman, Edward Redwood City, US 12 161
Li, Xiaofan Belmont, US 29 42
Lin, Songnian Holmdel, US 52 193
Solis, Willy San Mateo, US 4 4
Stafford, Ryan Foster City, US 50 113
Willingham, Aarron Mountain View, US 9 84
Yam, Alice Belmont, US 40 65
Yang, Junhao Milpitas, US 23 49
Yin, Gang South San Francisco, US 47 239

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