Methods for producing fabs and IgG bispecific antibodies

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United States of America Patent

PATENT NO 11820828
APP PUB NO 20190292268A1
SERIAL NO

16465689

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Abstract

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Methods for producing Fabs and IgG bi-specific antibodies comprising expressing nucleic acids encoding designed residues in the CH1/CL interface are provided. Also provided are Fabs and IgG bi-specific antibodies produced according to the provided methods as well as nucleic acids, vectors and host cells encoding the same.

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Patent Owner(s)

Patent OwnerAddress
ELI LILLY AND COMPANYLILLY CORPORATE CENTER PATENT DIVISION INDIANAPOLIS IN 46285

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Demarest, Stephen John San Diego, US 8 15
Froning, Karen Jean Escondido, US 6 5
Kuhlman, Brian Arthur Chapel Hill, US 9 23
Leaver-Fay, Andrew Philip Carrboro, US 4 5

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