Therapeutic compositions comprising anti-NRP2 antibodies
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United States of America Patent
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Nov 7, 2023
Grant Date -
Jun 3, 2021
app pub date -
Oct 2, 2020
filing date -
Oct 3, 2019
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Abstract
Provided are affinity matured and humanized antibodies and antigen-binding fragments thereof that specifically bind to human neuropilin-2 (NRP2) polypeptides, including those that modulate binding interactions between human NRP2 and at least one NRP2 ligand, and which thereby modulate subsequent NRP2-mediated downstream signaling events, including related therapeutic compositions and methods for modulating NRP2 activity and treating diseases such as NRP2-associated diseases.
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