Modified orthopoxvirus vectors

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United States of America Patent

PATENT NO 11802292
APP PUB NO 20200392535A1
SERIAL NO

16959632

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Abstract

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The disclosure relates to modified orthopoxvirus vectors, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified orthopoxvirus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences and safety. The viruses we have discovered are also amenable to large scale manufacturing protocols.

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Patent Owner(s)

Patent OwnerAddress
TURNSTONE BIOLOGICS CORP920 BROADWAY NEW YORK NY 10010

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bell, John C Ottawa, CA 29 323
Bernstein, Steven H Lawrenceville, US 5 2
Breitbach, Caroline J Somerville, US 4 2
Burgess, Michael F Chester, US 6 2
Huh, Michael S Gatineau, CA 5 3
Keller, Brian Andrew Ottawa, CA 3 1
Le, Boeuf Fabrice Gatineau, CA 13 30
Pelin, Adrian Ottawa, CA 5 3
Tang, Matthew Y Orleans, CA 5 3

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