2-amino-N-(arylsulfinyl)-acetamide compounds as inhibitors of bacterial aminoacyl-tRNA synthetase

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United States of America Patent

PATENT NO 11802110
SERIAL NO

16339542

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Abstract

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The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 2-amino-N-(arylsulfinyl)-acetamide compounds that, inter alia, inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase (aaRS) (e.g., bacterial leucyl-t RNA synthetase, LeuRS). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase; to treat disorders that are ameliorated by the inhibition (e.g., selective inhibition) of bacterial aminoacyl-tRNA synthetase; to treat bacterial infections; etc.

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Patent Owner(s)

Patent OwnerAddress
OXFORD DRUG DESIGN LIMITEDOXFORD OX1 1BY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Charlton, Michael London, GB 4 8
Edmund, Grace London, GB 2 1
Finn, Paul William London, GB 4 11
Jirgensons, Aigars Riga, LV 21 100
Loza, Einars Riga, LV 23 372

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