Engineered stem cells and cellular products produced and secreted by such cells, methods of preparing, and uses thereof

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 11795434
APP PUB NO 20200172871A1
SERIAL NO

16678856

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

There is disclosed a cardiac explant-derived stem cell (EDC), the cell comprising a gene encoding an intermediate-conductance Ca2+-activated K+ channel, and wherein the gene causes an overexpression of the intermediate-conductance Ca2+-activated K+ channel, and methods of producing same. There is also disclosed a method of producing engineered EDCs having a modulated bioelectric property, the method comprising: obtaining EDCs; introducing a KCNN4 gene into the EDCs to increase the expression of KCa3.1 channels, to produce engineered EDCs. There is also disclosed a composition for treating or ameliorating a damaged myocardium in a subject, the composition comprising extracellular vesicles isolated from cultures of engineered EDCs. There is also disclosed a method for treating or ameliorating a damaged myocardium in a subject, comprising administering the engineered EDCs or the extracellular vesicles isolated from cultures of engineered EDCs to the damaged myocardium of the subject.

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

Patent OwnerAddress
L'INSTITUT DE CARDIOLOGIE DE MONTREAL5000 BELANGER ST E MONTREAL H1T 1C8

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Davis, Darryl Ottawa, CA 3 45
Nattel, Stanley Montréal, CA 3 4
Parent, Sandrine Ottawa, CA 2 0
Vigneault, Patrick Montreal, CA 1 0

Cited Art Landscape

Load Citation

Patent Citation Ranking

Forward Cite Landscape

Load Citation

Maintenance Fees

Fee Large entity fee small entity fee micro entity fee due date
3.5 Year Payment $1600.00 $800.00 $400.00 Apr 24, 2027
7.5 Year Payment $3600.00 $1800.00 $900.00 Apr 24, 2031
11.5 Year Payment $7400.00 $3700.00 $1850.00 Apr 24, 2035
Fee Large entity fee small entity fee micro entity fee
Surcharge - 3.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 7.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00