Methods of treating endometriosis
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United States of America Patent
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Oct 24, 2023
Grant Date -
N/A
app pub date -
May 11, 2021
filing date -
Sep 30, 2016
priority date (Note) -
In Force
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Abstract
Methods for treating uterine fibroids, endometriosis, adenomyosis, or heavy menstrual bleeding in a subject, which include administering to the subject from 10 mg to 60 mg per day of N-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N′-methoxyurea, and from 0.01 mg to 5 mg per day of a hormone replacement medicament. The present disclosure has methods for reducing menstrual bleeding in a subject, reducing bone mineral density loss in a subject caused by administering a GnRH antagonist to the subject, suppressing sex hormones in a subject, reducing vasomotor symptoms or hot flashes in a subject, and reducing symptoms of decreased libido in a subject having uterine fibroids, endometriosis, or adenomyosis. Further provided are methods of maintaining blood glucose profile, maintaining lipid profile, and/or maintaining bone mineral density in a pre-menopausal woman being treated for one or more conditions or symptoms of endometriosis, adenomyosis, uterine fibroids, or heavy menstrual bleeding; and methods of contraception and treating infertility.

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- 15 United States
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Patent Owner(s)
Patent Owner | Address | |
---|---|---|
SUMITOMO PHARMA SWITZERLAND GMBH | AESCHENGRABEN 27 BASEL 4051 |
International Classification(s)

- [Classification Symbol]
- [Patents Count]
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Hibberd, Mark | Hampshire, GB | 9 | 33 |
Johnson, Brendan Mark | Chapel Hill, US | 14 | 39 |
Mudd,, Jr Paul N | Cary, US | 14 | 40 |
Rajasekhar, Vijaykumar Reddy | Apple Valley, US | 14 | 39 |
Seely, Lynn | San Mateo, US | 21 | 225 |
Sukhatme, Mayukh Vasant | Mamaroneck, US | 4 | 10 |
Tanimoto, Masataka | Osaka, JP | 4 | 10 |
Wollowitz, Susan | Lafayette, US | 44 | 901 |
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