Methods of treating endometriosis

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United States of America Patent

PATENT NO 11793812
SERIAL NO

17317769

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Abstract

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Methods for treating uterine fibroids, endometriosis, adenomyosis, or heavy menstrual bleeding in a subject, which include administering to the subject from 10 mg to 60 mg per day of N-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N′-methoxyurea, and from 0.01 mg to 5 mg per day of a hormone replacement medicament. The present disclosure has methods for reducing menstrual bleeding in a subject, reducing bone mineral density loss in a subject caused by administering a GnRH antagonist to the subject, suppressing sex hormones in a subject, reducing vasomotor symptoms or hot flashes in a subject, and reducing symptoms of decreased libido in a subject having uterine fibroids, endometriosis, or adenomyosis. Further provided are methods of maintaining blood glucose profile, maintaining lipid profile, and/or maintaining bone mineral density in a pre-menopausal woman being treated for one or more conditions or symptoms of endometriosis, adenomyosis, uterine fibroids, or heavy menstrual bleeding; and methods of contraception and treating infertility.

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Patent Owner(s)

Patent OwnerAddress
SUMITOMO PHARMA SWITZERLAND GMBHAESCHENGRABEN 27 BASEL 4051

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hibberd, Mark Hampshire, GB 9 33
Johnson, Brendan Mark Chapel Hill, US 14 39
Mudd,, Jr Paul N Cary, US 14 40
Rajasekhar, Vijaykumar Reddy Apple Valley, US 14 39
Seely, Lynn San Mateo, US 21 225
Sukhatme, Mayukh Vasant Mamaroneck, US 4 10
Tanimoto, Masataka Osaka, JP 4 10
Wollowitz, Susan Lafayette, US 44 901

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