Anti-IGFBP-3R antibodies and methods of treating an IGFBP-3R expressing cancer

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United States of America Patent

PATENT NO 11786585
SERIAL NO

17532397

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Abstract

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Insulin-like growth factor-binding protein 3 receptor (IGFBP-3R) agonists and methods of their use to treat diseases involving IGFBP-3 and IGFBP-3R are provided. The agonists may be antibodies or other molecules specific for binding to and activating IGFBP-3R. The agonists are used to treat e.g. cancer, metabolic syndrome and obstructive respiratory disorders. In addition, methods of diagnosing cancer and predicting the chance of recurrence, metastasis and/or survival by measuring the level of IGFBP-3R in tumor tissue are provided.

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Patent Owner(s)

Patent OwnerAddress
VIRGINIA COMMONWEALTH UNIVERSITYRICHMOND VA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cai, Qing Richmond, US 20 13
Oh, Youngman Glen Allen, US 11 40

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