Method for optimizing 5-hydroxytryptamine function in the brain for therapeutic purposes
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United States of America Patent
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Oct 10, 2023
Grant Date -
Apr 20, 2023
app pub date -
Oct 14, 2022
filing date -
Oct 14, 2021
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Abstract
Disclosed herein are methods of elevating brain extracellular 5-hydroxytryptamine (5-HTExt) and of treating psychiatric conditions and neurological disorders using continuous intravenous infusion of 5-hydroxytryptophan (5-HTP). The methods can be provided for treatment of acute suicidal ideation and/or acute worsening of a mood disorder. The methods can provide rapid onset of therapeutic effect while also having low incidence of acute or moderate adverse effects. Also described herein are compositions for use in the methods, including stable 5-HTP compositions for use in preparing infusate solutions.
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