Molecules with altered neonate Fc receptor binding having enhanced therapeutic and diagnostic properties
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United States of America Patent
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Sep 26, 2023
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Sep 10, 2019
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May 16, 2014
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Abstract
The present invention provides molecules, including proteins, more particularly, immunoglobulins whose in vivo half-lives are altered (increased or decreased) by the presence of an IgG constant domain, or FcRn binding fragment thereof (e.g., an Fc region or hinge-Fc region) (e.g., from a human IgG, e.g., human IgG1), that have modifications of one or more of amino acid residues in at least the CH3 domain.
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