Anti-PD-L1/anti-CD47 bispecific antibody

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United States of America Patent

PATENT NO 11739151
APP PUB NO 20210230277A1
SERIAL NO

16769108

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Abstract

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Provided are an anti-PD-L1/anti-CD47 bispecific antibody that has natural IgG characteristics and is in a highly stable heterodimer form without the heavy chain and light chain being mismatched, and a preparation method therefor. Either the first Fc chain or second Fc chain of the bispecific antibody comprises amino acid substitutions at positions 366 and 399, and the other comprises amino acid substitutions at positions 351, 407 and 409.

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Patent Owner(s)

Patent OwnerAddress
BEIJING HANMI PHARMACEUTICAL CO LTDNO 10 TIANZHU WEST ROAD ZONE A TIANZHU AIRPORT INDUSTRIAL ZONE SHUNYI DISTRICT BEIJING 101318 BEIJING CITY BEIJING CITY 101318

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kim, Maengsup Beijing, CN 11 52
Liu, Jiawang Beijing, CN 19 56
Song, Nanmeng Beijing, CN 13 38
Yang, Yaping Beijing, CN 25 165

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