Cell microinjection system with force feedback

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United States of America Patent

PATENT NO 11732275
APP PUB NO 20190292567A1
SERIAL NO

16364458

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Abstract

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A novel piezo-driven cell injection system with force feedback overcomes the unsatisfied force interaction between the pipette needle and embryos in conventional position control. By integrating semiconductor strain-gage sensors for detecting the cell penetration force and the micropipette relative position in real time, the developed cell microinjection system features high operation speed, confident success rate, and high survival rate. The effectiveness of the developed cell injection system is experimentally verified by penetrating zebrafish embryos. The injection of 100 embryos are conducted with separate position control and force control. Results indicate that the force control enables a survival rate of 86%, which is higher than the survival rate of 82% produced by the position control in the same control environment. The experimental results quantitatively demonstrate the superiority of force control over conventional position control for the first time.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF MACAUTHE UNIVERSITY OF MACAO TAIPA CHINA UNIVERSITY OF MACAO MACAO MACAO

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Xu, Qingsong Macau, CN 65 539

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