Self-assembling protein nanostructures displaying paramyxovirus and/or pneumovirus F proteins and their use
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United States of America Patent
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Aug 22, 2023
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app pub date -
Nov 10, 2021
filing date -
Apr 4, 2017
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Abstract
Disclosed herein are nanostructures and their use, where the nanostructures include (a) a plurality of first assemblies, each first assembly comprising a plurality of identical first polypeptides; (b) a plurality of second assemblies, each second assembly comprising a plurality of identical second polypeptides, wherein the second polypeptide differs from the first polypeptide; wherein the plurality of first assemblies non-covalently interact with the plurality of second assemblies to form a nanostructures; and wherein the nanostructure displays multiple copies of one or more paramyxovirus and/or pneumovirus F proteins or antigenic fragments thereof, on an exterior of the nanostructure.
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