Method for controlling encapsulation efficiency and burst release of water soluble molecules from nanoparticles and microparticles produced by inverse flash nanoprecipitation

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United States of America Patent

PATENT NO 11731099
SERIAL NO

16517510

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Abstract

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A method for controlling the encapsulation efficiency and burst release of water soluble molecules from nanoparticle and microparticle formulations produced by the inverted Flash NanoPrecipitation (iFNP) process and subsequent processing steps is presented. The processing steps and materials used can be adjusted to tune the encapsulation efficiency and burst release of the encapsulated water-soluble material. The encapsulation efficiency of the soluble agent in the particles and the burst release of the soluble agent from the particles can be controlled by: (1) the copolymers used in the assembly or coating process, (2) the degree of crosslinking of the nanoparticle core, (3) the incorporation of small molecule or polymeric additives, and/or (4) the processing and release conditions employed.

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Patent Owner(s)

Patent OwnerAddress
THE TRUSTEES OF PRINCETON UNIVERSITY87 PROSPECT AVENUE PRINCETON NJ 08544

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Markwalter, Chester E Princeton, US 7 10
Pagels, Robert F Princeton, US 11 28
Prud'homme, Robert K Princeton, US 100 2159

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