Bicyclic urea kinase inhibitors and uses thereof

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United States of America Patent

PATENT NO 11725011
APP PUB NO 20210147425A1
SERIAL NO

16953984

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present disclosure provides compounds of Formula (I), (II), and (III). The provided compounds are able to bind protein kinases (e.g., SIK) and may be useful in modulating (e.g., inhibiting) the activity of a protein kinase (e.g., SIK, (e.g., SIK1, SIK2, or SIK3)) in a subject or cell. The provided compounds may be useful in treating or preventing a disease (e.g., proliferative disease, musculoskeletal disease, genetic disease, hematological disease, neurological disease, painful condition, psychiatric disorder, or metabolic disorder) in a subject in need thereof. Also provided are pharmaceutical compositions, kits, methods, and uses that include or involve a compound described herein.

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Patent Owner(s)

  • THE GENERAL HOSPITAL CORPORATION; DANA FARBER CANCER INSTITUTE INC.; THE BROAD INSTITUTE, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Choi, Hwan Geun Chestnut Hill, US 69 786
Fisher, David E Newton, US 30 71
Gray, Nathanael S Boston, US 247 2143
Liang, Yanke Belmont, US 54 471
Mujahid, Nisma Spencerport, US 6 26
Shamji, Alykhan Somerville, US 13 63
Sundberg, Thomas Boston, US 17 379
Xavier, Ramnik Brookline, US 29 77

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