Microfluidic pH-stat for point of care (POC) enzyme diagnostics

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 11709146
APP PUB NO 20200173951A1
SERIAL NO

16701682

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

A microfluidic pH-stat with a specially-is designed slide and portable device can be used for point-of-care enzyme diagnostics. The slide includes a microchamber and a substrate for the enzyme being tested. The substrate is homogenized with the sample in the microchamber to form a test volume. The microchamber includes a working microelectrode that injects current to split water in the test volume to generate hydrogen ions and/or hydroxide ions and a micro-pH-electrode to measure a pH of the test volume; the slide also includes a reference microelectrode. The device includes a processor to adjust the injected current based on the pH of the test volume and determine an activity of the enzyme based on an amount the injected current is adjusted.

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

Patent OwnerAddress
CASE WESTERN RESERVE UNIVERSITY10900 EUCLID AVENUE CLEVELAND OH 44106

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cseefalvi, Tamas Cleveland, US 1 0
Gratzl, Miklos Cleveland, US 15 750
Stanton, John W Cleveland, US 7 16
Zhang, Zhehao Cleveland, US 1 0
Zorman, Christian Cleveland, US 5 2

Cited Art Landscape

Load Citation

Patent Citation Ranking

Forward Cite Landscape

Load Citation

Maintenance Fees

Fee Large entity fee small entity fee micro entity fee due date
3.5 Year Payment $1600.00 $800.00 $400.00 Jan 25, 2027
7.5 Year Payment $3600.00 $1800.00 $900.00 Jan 25, 2031
11.5 Year Payment $7400.00 $3700.00 $1850.00 Jan 25, 2035
Fee Large entity fee small entity fee micro entity fee
Surcharge - 3.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 7.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00