Method for preparing natural bioactive peptide Tubulysin U

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United States of America Patent

PATENT NO 11702444
APP PUB NO 20230099436A1
SERIAL NO

17984642

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Abstract

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A preparation method of a novel natural bioactive peptide Tubulysin U includes: dissolving a compound 2 in trifluoroacetic acid, heating under reflux to prepare an intermediate, reacting with a compound 3 and N,N-diisopropylethylamine to obtain a product, reacting the product with 2, 6-dimethylpyridine and tert-butyldimethylsilyl trifluoromethanesulfonate, adding sodium hydroxide after the reaction to prepare an intermediate acid, reacting the intermediate acid with a compound 6, HATU and N,N-diisopropylethylamine to obtain a product, adding triphenylphosphine to prepare an intermediate amine, adding a compound 8 and HATU to react, adding ammonium fluoride to prepare a first intermediate, adding sodium hydroxide to the first intermediate to prepare a second intermediate, adding acetic anhydride to the second intermediate to prepare a third intermediate, adding trifluoroacetic acid to the third intermediate to prepare a fourth intermediate, and adding formaldehyde and sodium cyanoborohydride to the fourth intermediate to react, thereby obtaining a target product.

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Patent Owner(s)

Patent OwnerAddress
WU ZHENGZHI518028 NO 2008 SUNGANG WEST ROAD SHENZHEN GUANGDONG PROVINCE SHENZHEN CITY GUANGDONG PROVINCE 518028
SHENZHEN INSTITUTE OF GERIATRICSNO 3002 SUNGANGXI ROAD FUTIAN DISTRICT SHENZHEN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Li, Limin Shenzhen, CN 42 397
Li, Zhiyue Shenzhen, CN 5 0
Liu, Zhanyan Shenzhen, CN 2 0
Long, Bohua Shenzhen, CN 4 24
Wu, Zhengzhi Shenzhen, CN 8 2

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