Quantification of absolute blood flow in tissue using fluorescence mediated photoplethysmography
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United States of America Patent
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Jul 11, 2023
Grant Date -
Apr 2, 2020
app pub date -
Sep 30, 2019
filing date -
Jun 14, 2013
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Abstract
A method and an apparatus for measuring a time-varying change in an amount of blood in a tissue include exciting a fluorescence agent in the blood, acquiring a time-varying light intensity signal during a pulsatile flow of the blood through the tissue volume, the pulsatile flow having a systolic and a diastolic phase resembling a conventional photoplethysmogram, and processing the acquired signal by applying a modified Beer-Lambert law to obtain the measurement of the time-varying change in the amount of blood in the tissue volume. The instantaneous molar concentration of the fluorescence agent is determined by utilizing a concentration-mediated change in a fluorescence emission spectrum of the fluorescence agent.
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