and its application in the species identification of hemocoagulase for injection

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United States of America Patent

PATENT NO 11692186
SERIAL NO

17389382

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Abstract

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The present invention provides a snake venom thrombin marker peptide of Agkistrodon Halys Pallas and an application of the snake venom thrombin-like enzyme in identifying species of Hemocoagulase for Injection. The application includes the following steps of: dissolving a to-be-detected sample and a reference substance of the marker peptide respectively to prepare a test solution and a reference solution, and conducting alkylation reduction on the test solution and the reference solution with dithiothreitol and iodoacetamide; after diluting products with an ammonium bicarbonate solution, adding enzyme for hydrolysis; and after enzymolysis is finished, conducting centrifugation at a high speed, and injecting a supernatan into a liquid chromatography-mass spectrometer for analysis. This method is simple, convenient and rapid, is strong in specificity, fills the gap in identifying the source of species of the snake venom thrombin-like enzyme of Agkistrodon Halys Pallas and improves the quality control level.

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Patent Owner(s)

Patent OwnerAddress
SHANDONG UNIVERSITY44 WENHUA WEST ROAD LIXIA DISTRICT JINAN SHANDONG 250012 250012
SHANDONG INSTITUTE FOR FOOD AND DRUG CONTROL250101 2749 XINLUO STREET HIGH TECH DEVELOPMENT ZONE JINAN CITY SHANDONG PROVINCE JINAN CITY SHANDONG PROVINCE 250101
AVANC PHARMACEUTICAL CO LTD55 SONGSHAN AVENUE TAIHE DISTRICT JINZHOU LIAONING 121013 121013

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chi, Lianli Shandong, CN 6 12
Du, Hongming Liaoning, CN 3 0
Gong, Liping Shandong, CN 4 0
Hang, Baojian Shandong, CN 5 3
Shi, Feng Shandong, CN 154 802
Wang, Congcong Shandong, CN 12 10
Wang, Fengshan Shandong, CN 4 0
Wang, Weijian Shandong, CN 20 203
Xian, Ruiqing Shandong, CN 4 0
Zhang, Qunye Shandong, CN 1 0

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