Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

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United States of America Patent

PATENT NO 11674159
APP PUB NO 20210222205A1
SERIAL NO

17220692

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Abstract

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The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.

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Patent Owner(s)

  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; UNIVERSITY OF VIENNA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Charpentier, Emmanuelle Berlin, DE 107 7336
Chylinski, Krzysztof Vienna, AT 107 2406
Doudna, Jennifer A Berkeley, US 223 4956
Jinek, Martin Berkeley, US 110 2779

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