Fusion proteins for ophthalmology with increased eye retention

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United States of America Patent

PATENT NO 11673942
APP PUB NO 20210024624A1
SERIAL NO

17066215

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Abstract

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The combination of a first binding site specifically binding to a target associated with an eye disease and a second binding site specifically binding to a target influencing the retention in the eye a multispecific binder provides for improved intravitreal retention compared to a monospecific binder. The second binding site specifically binds to a compound/molecules found in the extracellular matrix (ECM) in vitreous humor/retina. This compound of the extracellular matrix has to be present in amounts allowing a sufficient loading/dose of the drug to be bound. It has been found that collagen, especially collagen II, is a suitable compound in the ECM in the vitreous humor for this purpose. Thus, herein is reported a multispecific binder comprising a first binding site specifically binding to a therapeutic ocular target, and a second binding site specifically binding to collagen II.

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Patent Owner(s)

Patent OwnerAddress
HOFFMANN-LA ROCHE INCLITTLE FALLS NJ

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Huelsmann, Michael Habach, DE 3 2
Kopetzki, Erhard Penzberg, DE 81 1203

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