Near-infrared II polymer fluorescent microsphere and method for preparing same

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United States of America Patent

PATENT NO 11668706
APP PUB NO 20200181485A1
SERIAL NO

16632889

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Provided are a near-infrared II polymer fluorescent sub-microsphere and a method for preparing the same. The method includes steps of 1) dissolving fluorochrome in a water-immiscible organic solvent, thus obtaining a fluorochrome solution; 2) distributing a polymer sub-microsphere into a sodium dodecyl sulfonate solution, thus obtaining a sub-microsphere solution with the polymer sub-microsphere as a carrier for the fluorochrome; 3) subjecting a first mixture of the fluorochrome solution and the sub-microsphere solution to ultrasonic treatment, thus obtaining an emulsion; 4) swelling the emulsion such that the fluorochrome solution enters nanopores formed during swelling of the polymer sub-microsphere, thus obtaining a second mixture; and 5) heating the second mixture to volatilize the organic solvent, such that the fluorochrome is crystallized out and encapsulated in the nanopores, thus obtaining the near-infrared II polymer fluorescent sub-microsphere.

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Patent Owner(s)

Patent OwnerAddress
NIRMIDAS BIOTECH INC2458 EMBARCADERO WAY PALO ALTO CA 94303
WWHS BIOTECH INCRM505 BUILDING NO 1 SHENZHEN NATIONAL BIOLOGICAL INDUSTRY BASE EAST JINXIU ROAD PINGSHAN DISTRICT SHENZHEN GUANGDONG 518122

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Liang, Yongye Shenzhen, CN 7 77
Liao, Tao Shenzhen, CN 8 1
Tang, Meijie Shenzhen, CN 7 19
Wang, Guoxin Shenzhen, CN 13 34
Yang, Qinglai Shenzhen, CN 1 0
Zhao, Su Shenzhen, CN 14 47

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