Peptoid compound and manufacturing method thereof, oligomer, pharmaceutical composition, and kit

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United States of America Patent

PATENT NO 11591370
APP PUB NO 20210206808A1
SERIAL NO

16646320

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Abstract

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A peptoid compound, a manufacturing method of a peptoid compound, an oligomer, a pharmaceutical composition, use of the pharmaceutical composition in the preparation of a medicament for detecting or diagnosing a disease related to tyrosine kinase HER2, and a kit for identifying circulating tumor cells are provided, the peptoid compound includes: a cysteine (Cys) subunit, a butanediamine (Nlys) subunit, a 3,4-methylenedioxybenzylamine (Npip) subunit, a 3-aminopropanic acid (Nce) subunit and a 1-naphthylamine (Na) subunit, and both the peptoid compound and the oligomer have a strong ability to bind to HER2 protein on surfaces of circulating tumor cells (CTCs), and a technology of diagnosing breast cancer on the basis of the peptoid compound can realize non-invasive and label-free rapid diagnosis, in addition, the methods for synthesizing the peptoid compound and the oligomer are simple, the preparation efficiency is high, and the production cost is low.

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Patent Owner(s)

Patent OwnerAddress
BOE TECHNOLOGY GROUP CO LTDNO 10 JIUXIANQIAO RD CHAOYANG DISTRICT BEIJING 100015
BEIJING BOE TECHNOLOGY DEVELOPMENT CO LTDROOM 407 BUILDING 1 NO 9 DIZE ROAD BDA DAXING DISTRICT BEIJING 100176

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Yin, Yudan Beijing, CN 18 4
Zhao, Zijian Beijing, CN 26 8

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