Payload and linker designs for platinum-acridine anticancer agents and methods thereof

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United States of America Patent

PATENT NO 11591357
APP PUB NO 20200181185A1
SERIAL NO

16642074

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Abstract

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The present invention relates to payloads containing functionalized platinum-(benz)acridine hybrid agents as cytotoxic warheads and a method of synthesizing the payloads. The payload can be regioselectively conjugated to a biologically active moiety in order to facilitate the delivery and/or enhance the activity of the platinum compound.

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Patent Owner(s)

Patent OwnerAddress
WAKE FOREST UNIVERSITY391 TECHNOLOGY WAY SUITE 199 WINSTON-SALEM NC 27101

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bierbach, Ulrich Winston-Salem, US 13 38
Wang, Hanwen Winston-Salem, US 4 4
Yao, Xiyuan Winston-Salem, US 3 1

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